GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs6088813 | 1 | rs4911496 | chr20:33972053 | CPNE1 | chr20:34213968-34262539:- | -0.24 | -4.91 | 1.27E-6 | Height |
| THCA | cis | rs6088813 | 1 | rs4911496 | chr20:33972053 | GDF5 | chr20:33897002-34042568:- | 0.16 | 3.6 | 0.000347 | Height |
| THCA | cis | rs6088813 | 1 | rs4911496 | chr20:33972053 | UQCC | chr20:33890383-33999833:- | -0.28 | -9.6 | 4.6E-20 | Height |
| THCA | cis | rs4915077 | 1 | rs4915073 | chr1:108325879 | VAV3 | chr1:108113782-108507545:- | 0.49 | 6.69 | 6.44E-11 | Hypothyroidism |
| THCA | cis | rs4915077 | 1 | rs4915076 | chr1:108359505 | VAV3 | chr1:108113782-108507545:- | 0.56 | 8.05 | 6.58E-15 | Hypothyroidism |
| THCA | cis | rs4915077 | 1 | rs4915077 | chr1:108366016 | VAV3 | chr1:108113782-108507545:- | 0.57 | 8.13 | 3.62E-15 | Hypothyroidism |
| THCA | cis | rs491567 | 1 | rs491567 | chr15:53946593 | WDR72 | chr15:53805938-54051859:- | 0.14 | 3.44 | 0.000644 | Chronic kidney disease;Glomerular filtration rate (creatinine);Glomerular filtration rate in non diabetics (creatinine) |
| THCA | cis | rs4917385 | 1 | rs4917385 | chr10:105003721 | C10orf32 | chr10:104613967-104624718:+ | -0.18 | -5.13 | 4.25E-7 | Systemic lupus erythematosus |
| THCA | cis | rs11190604 | 1 | rs4917901 | chr10:102201773 | SEC31B | chr10:102246403-102289636:- | -0.3 | -10.18 | 3.73E-22 | Palmitoleic acid (16:1n-7) plasma levels |
| THCA | cis | rs4509693 | 1 | rs4917908 | chr10:102502674 | FBXW4 | chr10:103370422-103454743:- | -0.17 | -3.35 | 0.000873 | Alzheimer's disease |
| THCA | cis | rs975752 | 1 | rs4919429 | chr10:101938630 | BLOC1S2 | chr10:102033713-102046439:- | -0.66 | -8.26 | 1.43E-15 | Schizophrenia |
| THCA | cis | rs975752 | 1 | rs4919429 | chr10:101938630 | CWF19L1 | chr10:101992055-102027437:- | -0.58 | -5.9 | 6.84E-9 | Schizophrenia |
| THCA | cis | rs11190604 | 1 | rs4919464 | chr10:102221195 | SEC31B | chr10:102246403-102289636:- | -0.3 | -10.24 | 2.25E-22 | Palmitoleic acid (16:1n-7) plasma levels |
| THCA | cis | rs11190604 | 1 | rs4919465 | chr10:102221703 | SEC31B | chr10:102246403-102289636:- | -0.3 | -10.24 | 2.25E-22 | Palmitoleic acid (16:1n-7) plasma levels |
| THCA | cis | rs11190604 | 1 | rs4919466 | chr10:102241213 | SEC31B | chr10:102246403-102289636:- | -0.3 | -10.08 | 8.78E-22 | Palmitoleic acid (16:1n-7) plasma levels |